On-loan duo Nathan Ake and Kwesi Appiah are unavailable as they are cup-tied but fellow loanees Nathaniel Chalobah and Jamie Mackie can play.
Arsenal midfielder Jack Wilshere could make his first appearance after recovering from an ankle problem.
However, Mikel Arteta and Alex Oxlade-Chamberlain are still not fit. Wojciech Szczesny will start in goal.
France defender Mathieu Debuchy may also be included in the squad again, having been out since January after needing shoulder surgery.
There have been 24 goals in the last three meetings between Arsenal and Reading, which bodes well for the neutral as the Berkshire club taste their first FA Cup semi-final since 1927. You'd need to be very old and have a very good memory to recall that one (a 3-0 defeat to Cardiff at Molineux).
Arsenal only need short memories for something of a cautionary tale. Twelve months ago they were eight minutes away from being beaten by another Championship club, Wigan, at this stage. In the end
Arsenal squeaked through on penalties to what was a record-equalling 18th FA Cup final.
There are big differences though - 12 months ago, rather than being on an eight-game winning streak, Arsenal had gone four games without a win - one of which had been a
6-0 defeat by Chelsea. Against Wigan, rather than having Olivier Giroud and Alexis Sanchez threatening their opponent's goal it was Lukas Podolski and Yaya Sanogo.
Reading haven't had an easy route to Wembley; they may not have faced Premier League opposition but they've been drawn away in every round and got the better of both Derby and Cardiff. They are all but safe in the Championship but haven't won a game since the quarter-final replay victory over Bradford City a month ago.
In the pugnacious Pavel Pogrebnyak and rumbustious Jamie Mackie they have strikers who are a handful on most days. Jordan Obita and Michael Hector are excellent defensive prospects, Nathaniel Chalobah - on loan from Chelsea - is a real presence in midfield and Garath McCleary and former Arsenal trainee Hal Robson-Kanu offer a threat from wide areas.
Arsenal will not take them lightly, but Reading boss Steve Clarke is probably correct when he says that his side will need to play "the perfect game" to win.
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